Table 3.
Ortholog Conservation in Model Invertebrate Animals
| Data sets (no. of human proteins) | Orthologs | ||
| C. elegans | D. melanogaster | ||
| Positionally cloned genes mutated in specific human diseases (84) | 25 | 13 | |
| Biosynthetic enzymes (30) | 24 | 18 | |
| purine biosynthesis (6) | 5 | 4 | |
| arginine and proline biosynthesis (8) | 6 | 6 | |
| sterol biosynthesis (11) | 8 | 5 | |
| folate biosynthesis/5 | 5 | 3 | |
| Leukocyte surface antigens (151) | 15 | 5 | |
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↵The list of proteins is available online athttp://www.sequana.com/publications/model_organisms.
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↵Three human enzyme sequences in this category are unavailable, so the yeast orthologs were used.
