Characterization and Comparison of the Human and MouseGLC1A Glaucoma Genes

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Figure 1.Figure 1.Figure 1.
Figure 1.

The three exons of the human and mouse GLC1A genes and flanking sequences are aligned in A, B, and C and are not continuous. Exon sequences are in uppercase letters; flanking sequences are in lowercase letters. (•) Nucleotides conserved between mouse and human. (A) Exon 1 and flanking promoter and intron 1 sequences. A subset of putative promoter and enhancer elements are underlined and labeled. (GR) GRE half-sites. A CA repeat polymorphism in the 5′ flanking region of the human GLC1A gene is underlined and labeled here and in C (downstream of the humanGLC1A gene). (B) Exon 2 and flanking intron 1 and intron 2 sequences. (C) Exon 3 and flanking intron 2 and downstream sequences. Poly(A) signal sequences are underlined and labeled. GenBank accession nos. for these sequences are AF049791–AF049796.

This Article

  1. Genome Res. 8: 377-384

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