Multiple Members of a Third Subfamily of P-Type ATPases Identified by Genomic Sequences and ESTs

Genomic structure of C. elegans P-type ATPases. Coding regions are shown interrupted by introns (black vertical lines with intron length in base pairs at the top). Putative transmembrane domains are black bars; P-type ATPase consensus regions, with numbers corresponding to those in Fig. 3, are marked by asterisks. Intron/exon information for the Na⁺/K⁺–ATPase α-subunit CENAK was translated fromeat-6 gene (GenBank accession no. U18546). Coding regions for the plasma membrane Ca²⁺ transporter CPMCA and for the five new subfamily members were predicted by Genefinder from the cosmids W09C2 (GenBank accession no. Z68221), Y49E10 (Z98866), T24H7.5 (U28940), W09D10 (Z93785), F36H2 (Z81078), VF36H2L (AL021466), and F02C9 (U80025), respectively, as described in Methods.