Phylogenomics: Improving Functional Predictions for Uncharacterized Genes by Evolutionary Analysis

Table 2.

Types of Molecular Homology

Homolog Genes that are descended from a common ancestor (e.g., all globins)
Ortholog Homologous genes that have diverged from each other after speciation events (e.g., human β- and chimp β-globin)
Paralog Homologous genes that have diverged from each other after gene duplication events (e.g., β- and γ-globin)
Xenolog Homologous genes that have diverged from each other after lateral gene transfer events (e.g., antibiotic resistance genes in bacteria)
Positional homology Common ancestry of specific amino acid or nucleotide positions in different genes

This Article

  1. Genome Res. 8: 163-167

Preprint Server