Allele Frequency Distributions in Pooled DNA Samples: Applications to Mapping Complex Disease Genes

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Figure 4.
Figure 4.

DNA pooling of HSCR-associated genetic markers. T and U parental allele frequencies estimated from direct genotyping and from two DNA pools (27 HSCR affected offspring and their parents) for markers on human chromosome 13q flanking the HSCR susceptibility gene EDNRB.For visual clarity, white and shaded stripes have been used to separate T and U frequencies on adjacent alleles. The legend follows that in Fig. 2.

This Article

  1. Genome Res. 8: 111-123

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