Novel Families of Putative Protein Kinases in Bacteria and Archaea: Evolution of the “Eukaryotic” Protein Kinase Superfamily

↵The SWISSPROT version of this protein sequence (P37562) selects an upstream start codon adding 42 residues at the amino terminus, which includes homology to conserved region I of the ePKs.

↵This ORF appears to be a fragment of a protein kinase gene containing homology to conserved regions I, II, and III.

↵A correction of the original E. colisequence has joined the YigQ, YigR, and YigS ORFs into this single ORF.

↵This ORF was not annotated in the originalH. influenzae sequence (Koonin 1997).

↵This appears to be a single ORF that has been split by a frameshift. For the purposes of this analysis, the two ORFs were simply fused.

↵This ORF appears to be a fragment of a protein kinase gene containing homology to conserved regions I and II of the ePKs.

↵See legend to Fig. 1 for a description of this sequence.

↵Our analysis of the “typical” protein kinases in yeast agrees with that of Hunter and Plowman (1997), with two additions. Specifically, we have included YJL057C and YGL083W. Examination to the sequence of YGL083W suggests it may be inactive, but it is clearly related to the ePKs.

↵See legend to Fig. 1 for a description of this sequence.

↵This estimate is for those sequences present in the Wormpep 13 database, which contains ∼85% of the completeC. elegans genome.