Figure 1.
Refinement of the EPMR region by meiotic breakpoint mapping. DNA marker genotypes across the EPMR locus in two segments of the extended pedigree from Northern Finland (Hirvasniemi et al. 1994). The haplotypes reveal key recombination events that reduce theEPMR minimum genetic region to <1 cM. Both recombinations occur in healthy siblings (arrows). Disease homologs are in boldface type. The boxed regions contain the segment of recombinant chromosome marking the sites of chromosomal recombination. (O) Untyped alleles.
