Figure 6.
Generation of hybrid SMN genes. (A) The two highly homologous copies of the SMN gene, centromeric SMN(CENSMN) and telomeric SMN (TELSMN) are depicted. The two copies are distinguished by base changes in introns (IN) 6 and 7 and exons (EX) 7 and 8 as shown. The bases within introns and exons are depicted as lower- and uppercase, respectively. (B) Of the 42 patients examined (Hahnen et al. 1996), 40 showed hybrid genes containing CENSMN introns 6 and 7 and exon 7, and TELSMN exon 8; 2 of the 42 patients had a hybrid gene containing CENSMN intron 6 and exon 7, and TELSMNintron 7 and exon 8.
