Recombination Hot Spots and Human Disease

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Steroid 21-hydroxylase gene mutations as a result of exchange of sequence between the functional 21-hydroxylase gene (21B) and its closely related pseudogene (21A). The duplicated complement genes (C4A and C4B) and steroid 21-hydroxylase genes (21A and 21B) located on tandem 30-kb repeats are shown. Unequal crossover or unequal sister chromatid exchange results in either formation of a fusion gene or complete deletion of the functional 21-hydroxylase gene.

This Article

  1. Genome Res. 7: 773-786

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research