Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region

Table 1.

Percent Identity among Human, Mouse, andDrosophila SIMs

SIM2s SIM2 Sim1 Sim2 sim
nt aa nt aa nt aa nt aa nt aa
SIM1 (1–351) 74.4 87.2 74.4 87.2 88.6 98.9 76 88.9 58.3 71.8
SIM2 (1–351) 72.6 87.7 89.5 96.9 57 70.9
Sim1 (1–351) 75.1 89.4 55 72.1
Sim2 (1–351) 56.1 71.2
SIM1 (352–end) 28.4 19.6 22.9 18 86.2 93.7 22.8 16 20.8 11.7
SIM2s (352–end) 82.1 81.3 25.5 17.3 69.2 68 20.1 11.4
SIM2 (352–end) 22.2 15.8 82.6 81.4 19.8 9.7
Sim1 (352–end) 21.5 15.3 21.4 10.7
Sim2 (352–end) 20.1 9.4
  • Percent identity on the nucleotide (nt) and amino acid (aa) level (calculated using ClustalW 1.6). The GenBank accession numbers of the different SIM sequences used are as in Fig. 1.

This Article

  1. Genome Res. 7: 615-624

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