Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region

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Figure 2.
Figure 2.

The conserved domains bHLH, PAS1, PAS2, and HST of the SIMs are shown schematically together with their alignments to domains from additional proteins. (Red) Identical amino acids; (blue) conserved amino acids. The GenBank numbers of the different SIM sequences used are as in Fig.1; trh (U33427), Drosophila trachealess; sima (U43090),Drosophila similar; hHIF-1a (U22431), humanhypoxia-induciblefactor-1α. SIM2s represents the 570-amino-acid short isoform of SIM2. An asterisk (*) denotes identical and a period (.) denotes conserved amino acids.

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  1. Genome Res. 7: 615-624

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