Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region

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Figure 1.
Figure 1.

Comparison of human, mouse, and Drosophila SIM-predicted polypeptides. SIM1 (GenBank accession no. U70212) and SIM2 (U80456), human SIMs; Sim1 (D79209) and Sim2 (D63383), mouse SIMs; dsim (M19020),Drosophila single minded. SIM2s (U80457) represents the 570-amino-acid short isoform of SIM2. An asterisk (*) denotes identical and a period (.) denotes conserved amino acids, respectively. Amino acid color codes: (Red) Identical among all sequences; (blue) conserved among all sequences; (purple) identical between mouse and human SIM1; (turquoise) identical between mouse and human SIM2; (dark yellow) identical among all mammalian SIM proteins. SIM2s is shown from its point of divergence with SIM2.

This Article

  1. Genome Res. 7: 615-624

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