The E6–AP Ubiquitin–Protein Ligase (UBE3A) Gene Is Localized within a Narrowed Angelman Syndrome Critical Region

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Figure 2.
Figure 2.

Detection of the t(14;15) cryptic translocation breakpoints. An 8-kbEcoRI fragment from cosmid 24 detects a single translocation junction fragment in EcoRI-digested DNA from the mother but not from the child, who is unbalanced. Both der(14) and der(15) breakpoints are seen in the HindIII panel, but the unbalanced, affected child has only the der(14) and not the der(15) chromosome, therefore displaying only one of the two breakpoint fragments seen in the mother.

This Article

  1. Genome Res. 7: 368-377

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