Table 3.
Nonsynonymous and Synonymous Mutation Rates of the Five Loci in the BTK Region
| Gene | Nonsynonymous (×1010) | Synonymous (×109) |
| Method 1 | ||
| BTK | 0.49 ± 0.15 | 2.22 ± 0.21 |
| FCI-12 | 1.51 ± 0.68 | 2.42 ± 0.59 |
| FTP-3 | 0.27 ± 0.13 | 1.53 ± 0.19 |
| GLA | 8.17 ± 0.81 | 2.58 ± 0.30 |
| L44L | 0.00 | 2.06 ± 0.48 |
| Method 2 | ||
| BTK | 0.48 ± 0.14 | 2.53 ± 0.24 |
| FCI-12 | 1.46 ± 0.66 | 2.82 ± 0.71 |
| FTP-3 | 0.26 ± 0.13 | 1.66 ± 0.21 |
| GLA | 8.01 ± 0.79 | 2.76 ± 0.33 |
| L44L | 0.00 | 2.37 ± 0.59 |
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Average substitution rate/nucleotide ± s.d.
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↵Methods 1 and 2 differ only in their estimation of the α/β ratio, a measurement of transitional and transversional substitution rates (see Ina 1995).
