Bovine natural resistance associated macrophage protein 1 (Nramp1) gene.

  1. J Feng,
  2. Y Li,
  3. M Hashad,
  4. E Schurr,
  5. P Gros,
  6. L G Adams, and
  7. J W Templeton
  1. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4467, USA.

Abstract

The Bcg/Ity/Lsh locus is a major gene controlling early phases of infection with intracellular parasites in mice. Natural resistance associated macrophage protein 1 (Nramp1) has been shown to be the Bcg gene in mice. Analysis of a bovine cDNA homolog of murine Nramp1, designated as bovine NRAMP1, predicted a 548-amino-acid protein with hydrophobic domains, an amino-terminal SH3-binding domain, and a conserved consensus transport motif. Northern blotting indicated that bovine NRAMP1 was expressed primarily in macrophages and tissues of the recticuloendothelial system. Bovine NRAMP1 was mapped to BTA 2 within syntenic loci conserved on HSA 2q and MMU 1.

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  1. doi: 10.1101/gr.6.10.956 Genome Res. 6: 956-964 Copyright © Cold Spring Harbor Laboratory Press

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