Figure 5.
Integrative analysis of aging and PD-associated gene expression changes. (A) Schematic of integration analysis between mouse and human single-cell data sets (Smajić et al. 2022) to identify consensus cell types and common age- and PD-associated genes. DaNs, dopaminergic neurons. (B) Heat map showing age-associated differentially expressed genes, with evidence of altered expression in PD across consensus cell types shown in the bottom panel. GO terms of genes with at least three evidence points in the GeneCards (Stelzer et al. 2016) database are displayed at the bottom.
