Inference of subclass-specific cCRE–gene links in the mouse substantia nigra. (A) Schematic of the computational strategy for linking chromatin accessibility of cCREs to expression of target genes for each cell subclass. (B) Bar plot showing the number of significantly (FDR < 0.1) correlated cCRE–gene pairs identified in each cell subclass. (C) Venn diagram showing the overlap of genes linked by cCREs and age-associated DEGs in oligodendrocytes. (D) Venn diagram showing the overlap of cCREs linked to genes and age-associated DACs in oligodendrocytes. (E) Genome Browser tracks of aggregate chromatin accessibility profiles and RNA signals for representative subclasses at selected age-associated DAC and DEG pairs.
