Minimizing reference bias with an imputed personalized reference

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Figure 7.
Figure 7.

Precision-recall measures for overall variants of HG001–HG005 samples. “Giraffe” refers to the use of the standard VG Giraffe aligner. Workflows are indicated within the parentheses following “Giraffe” and “LevioSAM2.” The terms Imputefirst_c5 and Imputefirst_c20 in the parentheses indicate the chosen downstream analysis workflows of BBBC5 and BBBC20 for the sample. Benchmark in the parentheses refers to the workflow when run using the GIAB truth VCF file for the sample.

This Article

  1. Published in Advance March 5, 2026, doi: 10.1101/gr.280989.125 Genome Res. 36: 740-753

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