Figure 2.
Lung FIE genes are under positive selection and include both known cancer genes and predicted novel drivers in paralogs that are also likely to affect protein function. (A) FIE genes (score ≥ 3) were under positive selection (dN/dS > 1.5). (B) FIEs in ERBB tyrosine–protein kinase paralogs EGFR* (lung), ERBB4* (lung), and ERBB2* (pancancer). (C) Ras small monomeric GTPase with LUAD FIEs in genes RRAS2 and RIT within the same FunFam. (D) Rac family small GTPase with LUSC FIEs in genes RAC1* and RAC2 within the same FunFam. (*) Known cancer genes from CGC.
