Convergent tissue composition in species living in an arid environment. Cell proportions were estimated by deconvolution using rat scRNA-seq data. (A) Principle of the method. UMAP redrawn from selected samples from Balzer et al. (2023). All cells from the scRNA-seq data except immune cells were used. (B,D) PCA on cell-type proportions is presented for the Total_expr and Murinae_expr data sets. Centroids are represented for species living in a mesic (green) and arid (orange) environment. (C) Cell proportions for species of the Total_expr data set, segregated by habitat. P-values of linear models testing for an effect of habitat accounting for the rodent family are indicated. (E) Correlations of Murinae coexpression modules (shown in Fig. 3G) with cell proportions, colored according to key. Cell types are abbreviated as follows (see also schema of panel A): endothelial cells (Endo), stroma cells (Stroma), proximal tubule cells (Prox tub), loop of Henle (LOH), distal convoluted tubule (DCT), connecting tubule (CNT), collecting duct principal cells (PC), and collecting duct intercalated cells (IC), immune cells (Immune).
