Figure 2.
Chromatin accessibility at the XIST locus across human heart cell types. (A) Multiomic scATAC/RNA-seq signal and expression (split by sex) across cell types. MACS2-called peaks are represented as “cell-type peaks.” The normalized signal across all cells and fragments for 100 random cells are presented above the XIST gene locus, with introns and exons as thin and thick green lines, respectively. (B) A zoomed-in view of scATAC-seq signal for male (blue) and female (brown) glia. (A,B) The red highlighted region represents the glia-specific peak (Chr X: 73,841,364–73,841,611) called by MACS2.
