Figure 5.
Correlation between trio concordance and maximum difference in IGHV read recruitment, normalized depth between child and parent. Each point represents a trio, demonstrating the relationship between read dropout and inheritance pattern consistency. The regression line indicates that a lower read recruitment in any one parent results in a lower trio concordance, with a correlation of 0.357 (P = 4.79 × 10−19). Similar correlations of 0.222 (P = 5.40 × 10−8) and 0.301 (P = 9.34 × 1014) were found with IGLV and IGKV, respectively (see Supplemental Fig. 1), suggesting the presence of IG read dropout, likely owing to rearrangement.
