Cancer driver topologically associated domains identify oncogenic and tumor-suppressive lncRNAs

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Figure 5.
Figure 5.

Depletion of identified putative cancer driver lncRNAs impairs or promotes the proliferation of prostate cancer cells. lncRNA expression level and cell proliferation of prostate cancer cell line LNCaP with each putative oncogenic lncRNA (A) or tumor-suppressive lncRNA (B) disrupted by CRISPR-Cas9 guide RNA p1, p2, or under control condition. Bar plot to show lncRNA expression level and line plot to show cell proliferation.

This Article

  1. Published in Advance May 27, 2025, doi: 10.1101/gr.280235.124 Genome Res. 35: 1842-1858

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