Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

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Figure 7.
Figure 7.

Dynamic barriers are required for agreement with multiple features of experimental data. (A) Range of barrier bound times from the dynamic barriers model in agreement with experimental data based on FRiP, insulation score, dot score, and vermicelli formation. Highlighted area (gray) indicates region of agreement across metrics (τb between 10 and 15 min). (B) Consequence of dynamic barrier model: long-lived extruders can sequentially bypass a series of dynamic barriers. This can equalize contact frequencies between a long-lived barrier, acting as an anchor (left site, dark red), and multiple downstream dynamic barrier positions (right three sites, lighter red).

This Article

  1. Genome Res. 35: 1745-1757

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