ATAC-seq data in C2C12 cells show that CTCF binding is largely lost in mitosis. (A–C) ATAC-seq data of nonsynchronized (A) and mitotically synchronized (B) C2C12 cells represented in V-plots as a pile-up on all interphase-bound CTCF sites (5827 sites total), as well as a side-by-side comparison of V-plots for nonsynchronized and mitotically synchronized cells on interphase bound CTCF sites. (D–F) ATAC-seq data of nonsynchronized (D) and mitotically synchronized (E) C2C12 cells represented in V-plots as a pile-up on all mitotic-bound CTCF sites (526 sites total), and a side-by-side comparison of the footprint of mitotically bound CTCF sites in nonsynchronized and mitotic cells (F).
