Discovery of treatment context–specific eQTL effects across cell types. (A) Number of eGenes identified in each cell type, classified as “standard” (blue) or oxygen-responsive (red) according to contexts in which effect sizes differ by less than twofold. Conditions with shared effect sizes are connected by gray lines, leaving black “condition-specific” effects. Total eQTLs of each category are indicated by asterisks (right axis). (B) Number of eGenes identified in each cell type, classified by sharing across oxygen treatment conditions and detection in normoxia condition. Light and dark shades of red and blue categories, respectively, sum to the blue and red categories shown in A. (C) Fraction of eGenes identified in this study that are classified as eGenes in GTEx cerebral cortex tissues (see Methods). Treatment context-specific eGenes that were not detected in control conditions were less likely to be found in GTEx (P = 0.01636, one-sided paired Wilcoxon test of oxygen-insensitive category against oxygen-responsive/undetected in normoxia category).
