Figure 1.
A panel of brain organoids yields diverse cell types across individuals. (A) Workflow of data collection. Brain organoids were first differentiated (see Methods) and adapted to physiological oxygen before 24-h exposure to high, low, or control oxygen levels. Data shown in this figure are taken from the 10% “normoxia” condition. (B) UMAP representation of organoid single-cell transcriptomes highlighting principal cell types obtained across all individuals in our iPSC panel in the normoxia condition. (C) Proportion of cells from each parental cell line by annotation, with colors corresponding to the UMAP shown in B.
