Accurate short-read alignment through r-index-based pangenome indexing

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Figure 1.
Figure 1.

Top 75 haplotype matches for HG005 MHC-aligned reads. Each bar shows the percentage of HG005 MHC-aligned reads that best align to a specific haplotype in the pan-MHC Chr 6 pangenome, using alignments determined by Moni-align. The percentage reflects an average across five read subsamples, with error bars indicating the standard deviation. Bar colors broadly represent the population origin of each haplotype: red for Southeast Asian, green for South American, and blue for African ancestry. Additionally, the black bar represents GRCh38, and the white bar represents T2T-CHM13.

This Article

  1. Genome Res. 35: 1609-1620

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