Verkko2 integrates proximity-ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding

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Figure 4.
Figure 4.

Verkko2 results on the HPRC year 1 assemblies. The T2T statistics are computed as before. QV and phasing error are computed using yak, and the average of both haplotypes is reported. The core genes are computed using compleasm and reported for each haplotype. The dup categories report single-copy genes present more than once in a haplotype. Because of natural variation, a small number (<1%) of duplicated genes is expected. The missing gene categories report single-copy genes not present in the assembly, excluding the sex chromosomes. The stability of duplicated and missing genes across all samples supports that Verkko2 is accurately reconstructing the full sequence for both haplotypes.

This Article

  1. Genome Res. 35: 1583-1594

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