Verkko2 integrates proximity-ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding

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Figure 3.
Figure 3.

Comparison of tested assemblers with all statistics measured as before. Verkko Hi-C has the highest T2T scaffold rate (except on chicken), followed by Verkko2 trio. Both versions of Hifiasm are comparable to Verkko1. With the exception of Hifiasm Hi-C on chicken and HG00733, all assemblers have comparable hamming error rates. Verkko1 has a consistently higher rate of missing genes compared with other assemblies. All assemblers were run on the NIH Biowulf compute cluster.

This Article

  1. Published in Advance May 19, 2025, doi: 10.1101/gr.280383.124 Genome Res. 35: 1583-1594

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