An iPSC-based model of 47,XYY Jacobs syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with male X aneuploid cells

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Figure 3.
Figure 3.

Transcriptomic profiling of sex-chromosome gene expression in 47,XYY cells. Venn diagrams of shared NPY DEGs (A) and PAR DEGs (B) in 47,XYY versus 46,XY fibroblasts, iPSCs, and NSCs. FDR < 0.05 and LogFC > |0.58|. (C,D) Scatter plot of the Log2FC comparison for NPY genes (C) and X- and Y-linked PARs (D) in fibroblasts versus iPSCs (left) and IPSCs versus NSCs (right). FDR < 0.01. NPY genes are indicated with blue dots. PAR genes are pink. The Pearson's correlation coefficient of the regression line (R) and P-values are shown.

This Article

  1. Published in Advance June 10, 2025, doi: 10.1101/gr.279716.124 Genome Res. 35: 1503-1517

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