Cover image

How single-cell biology reveals the intricate cellular responses to physical exercise is represented. The composition merges the dynamic forms of the human body running with a stylized data projection map, revealing a constellation of individual cell types and states. In this issue, single-cell transcriptome, chromatin, and regulatory circuit responses to acute endurance exercise in muscle are mapped, serving as a resource for understanding the molecular underpinnings of the metabolic and physiological effects of exercise. (Cover art was conceptualized by Antonio Cappuccio in collaboration with the authors of the article, Icahn School of Medicine at Mount Sinai. ChatGPT was used to generate figures aligned with the concept of combining a dynamic human form with a data projection map, which were then manually edited using Adobe Illustrator to correct anatomical proportions and improve clarity. [For details, see Rubenstein et al., pp. 1664–1677.])