BINDER achieves accurate identification of hierarchical TADs by comprehensively characterizing consensus TAD boundaries

Table 2.

Seven GO terms enriched by TUGs and TDGs

No. GO terms Genes Counts P-value
1 Protein phosphorylation Cd109, Cdc42bpa, Epha4, Fyn, Nek11, Sik3, Smg1, Taf3, Tek, Uvrag, Rsrc1, Csnk1g1, Cdkl5, Dapk2, Dclk2, Klhl3, Lats2, Map2k5, Map3k15, Map3k5, Ptpra, Ror1, Rps6ka3, Stk39, Sgk3, Tlk2 26 1.3 × 10−5
2 Protein dephosphorylation Cdc14a, Eya1, Eya2, Ppp2r3a, Ppp3ca, Ptpra, Ptprc, Ptprm, Ptprr, Ptpn14, Ssh2 11 8.0 × 10−5
3 Intracellular signal transduction Cdc42bpa, Fyn, Nek11, Rasa3, Arhgef6, Sik3, Tek, Adcy5, Asb3, Dapk2, Dclk2, Gucy1a2, Lats2, Plcg2, Pag1, Rps6ka3, Stk39, Sgk3, Tlk2 19 1.9 × 10−4
4 Positive regulation of transcription from RNA polymerase II promoter Arid2, Eya1, Glis3, Litaf, Prdm2, Smad3, Taf3, Wwp2, Wwox, Ablim2, Arnt2, Foxp1, Hivep1, Itga6, Kdm6a, Map2k5, Mllt10, Pax5, Ppargc1b, Ppp3ca, Rps6ka3, Runx2, Ssbp2, Ssbp3, Satb2, St18, Tnks, Tlr4, Tcf12, Tcf7l1, Tbl1x, Zfat, Zfp462, Zfp521, Zfp609, Zfp827 36 2.5 × 10−4
5 Circulatory system development Arid2, Abcc9, Foxp1, Kdm6a, Nxn 5 7.2 × 10−4
6 Regulation of gene expression Aff2, Dnmt3a, Prdm2, Thoc2, Drosha, Foxp1, Igf2bp3, Kdm6a, Nsd1, Plcg2, Pcbp3, Ptprc, Runx2, Satb2, Trim44, Zfp462, Zfp521, Zfp827 18 1.1 × 10−3
7 Chromatin organization Arid2, Dnmt3a, Eya1, Eya2, Eya4, L3mbtl3, Atg7, Ehmt1, Kdm6a, Ncor1, Nsd1, Satb2, Tox, Tlk2, Zfp462 15 1.4 × 10−3

This Article

  1. Genome Res. 35: 1194-1208

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