BINDER achieves accurate identification of hierarchical TADs by comprehensively characterizing consensus TAD boundaries

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Performance comparison between BINDER and other TAD callers. (A) Precision and the number of CTCF-matched boundaries on 10 kb GM12878 data. (B) Numbers of nested or nonnested TADs identified by BINDER and the other TAD callers. (C) Proportion of TADs of different levels identified by BINDER, SpectralTAD, and OnTAD (four bars of each TAD caller from left to right, representing the results on 10 kb GM12878, K562, NHEK, and HMEC data, respectively). (D) Lengths of TADs identified by BINDER and the others compared TAD callers on GM12878 data at resolutions of 50 kb, 25 kb, and 10 kb. (E–H) Number of TADs (E), weighted similarity (F), precision (G), and number of CTCF-matched TAD boundaries (H) on the whole-chromosome 10 kb GM12878 data at four downsampling rates.

This Article

  1. Published in Advance March 17, 2025, doi: 10.1101/gr.279647.124 Genome Res. 35: 1194-1208

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research