Multiple paralogs and recombination mechanisms contribute to the high incidence of 22q11.2 deletion syndrome

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Figure 3.
Figure 3.

Schematic visualization of 22q11.2 recombination breakpoints. The graph represents the 22q11.2 locus, its SDs, and known genes. Lines between LCR22s connect the proximal and distal breakpoint of a family-specific recombination. Solid red lines represent PATRR-mediated recombinations, and solid blue lines represent NAHR-mediated recombinations. The position of genes located in the involved recombination sequences is shown via blue or green vertical dotted lines.

This Article

  1. Published in Advance November 13, 2024, doi: 10.1101/gr.279331.124 Genome Res. 35: 786-797

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