Heterogeneous and novel transcript expression in single cells of patient-derived clear cell renal cell carcinoma organoids

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Figure 6.
Figure 6.

MDTs and MDT switch between ccRCC and non-ccRCC cells. (A) Distribution of the number of MDTs in PDOs. (B) Distribution of the number of cMDT in ccRCC2, ccRCC4, and ccRCC5 PDOs. (C) The number of overlapping isoforms (left panel) and genes (right panel) showing transcript-switching events across three data sets. (D) GO term enrichment analysis of genes commonly shows transcript-switching events in ccRCC2, ccRCC5, and ccRCC4 PDO data sets. (E) Exon structures of ccRCC (PB.8161.7) and non-ccRCC (PB.8161.6) MDTs. (F) UMI counts of cMDT and MDT APH1A transcripts in ccRCC and non-ccRCC cells.

This Article

  1. Published in Advance March 19, 2025, doi: 10.1101/gr.279345.124 Genome Res. 35: 698-711

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