Multisite long-read sequencing reveals the early contributions of somatic structural variations to HBV-related hepatocellular carcinoma tumorigenesis

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Figure 3.
Figure 3.

The characteristics of shared somatic SVs between adjacent nontumor and tumor tissues. (A) The frequency of each somatic SV type in different categories was shown: shared (in both adjacent nontumor and tumor tissues), T-specific (only in tumor tissues), and N-specific (only in adjacent nontumor tissues). (B) The length distribution of shared somatic SVs between adjacent nontumor and tumor tissues, as well as the SVs unique to either adjacent nontumor or tumor tissues. (C) An overview of genes overlapped by recurrently shared somatic SVs in adjacent nontumor and tumor tissues across patients. The left bar chart shows the mutation percentage across patients. The right bar chart displays the mutation percentage across samples.

This Article

  1. Genome Res. 35: 671-685

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