Multisite long-read sequencing reveals the early contributions of somatic structural variations to HBV-related hepatocellular carcinoma tumorigenesis

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

Identification of somatic SVs through multiregion LRS. (A) Schematic diagram showing the sampling locations for five patients. Blue dots represent adjacent nontumor tissues. Red dots represent tumor tissues. (B) Bar plots depicting the number of somatic SVs across individual samples, including INSs, DELs, DUPs, INVs, and TRAs. (C) Stacked plots showing the distribution of somatic SV lengths are categorized into two ranges: (50 bp, 1 kb) and (1 kb, 10 kb), stratified based on SV types. (D) The proportion of different SV size ranges within each somatic SV type.

This Article

  1. Genome Res. 35: 671-685

Preprint Server