Assessing DNA methylation detection for primary human tissue using Nanopore sequencing

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Figure 3.
Figure 3.

Comparison of HG002 immortalized cell line methylation calling between technologies. (A) Methylation proportion histograms for each technology. (B) Pairwise site-specific CpG methylation proportion comparison between technologies. (C) Site-specific CpG methylation proportion comparison between R10 and bisulfite sequencing. (D) RMSE values for pairwise comparisons between technology in Illumina 150 bp paired-end mappable regions as defined by BisMap. (E) RMSE for pairwise comparisons between technologies in Illumina 150 bp paired-end hard-to-map regions.

This Article

  1. Published in Advance March 7, 2025, doi: 10.1101/gr.279159.124 Genome Res. 35: 632-643

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