Taurine pangenome uncovers a segmental duplication upstream of KIT associated with depigmentation in white-headed cattle

Table 1.

Fourteen newly HiFi-assembled taurine haplotypes from Evolèner (EVO), Simmental (SIM), Rätisches Grauvieh (RGV), Original Braunvieh (OBV), or Brown Swiss (BSW) ancestry that were created with trio-binning (Trio) or a dual-assembly (Dual) approach

Sample/acronym HiFi Coverage (Gb) Haplotype Size Contigs N50 QV Gene completeness
GIR × SIM/SIM_2 91.4 Trio 3.16 886 52.5 53.1 99.6
RGV × SIM/SIM_3 140.1 Trio 3.21 682 89.9 58.8 99.5
RGV × SIM/RGVa 3.09 816 91.9 58.3 97.2
DWZ × EVO/EVO 139.1 Trio 3.19 527 92.1 57.5 99.7
Brown Swiss/BSW_3a 111.8 Trio 3.11 1031 80.6 46.7 98.4
Brown Swiss/BSW_4 3.11 857 71.2 47.1 98.3
Original Braunvieh/OBV_3 135.8 Dualb 2.95 2250 72.6 44.5 97.0
Original Braunvieh/OBV_4 2.99 1550 71.5 44.9 97.9
Braunvieh/BV_1 122.9 Dualb 2.95 2336 74.9 47.4 98.2
Braunvieh/BV_2 2.99 1755 72.4 47.6 96.6
Braunvieh/BV_3 145.0 Dualb 3.02 1701 83.2 43.1 95.1
Braunvieh/BV_4 2.85 2099 82.6 44.2 96.6
Braunvieh/BV_5 131.0 Dualb 3.05 1373 85.0 38.2 98.6
Braunvieh/BV_6 2.91 1681 74.6 39.1 96.5
  • Braunvieh (BV) indicates samples with both Brown Swiss and Original Braunvieh ancestry. HiFi coverage is given in gigabases per animal, and so is shared when both haplotypes are given. N50 is calculated with respect to the ARS-UCD1.2 size. The QV score is estimated with Merqury from short reads. Gene completeness is calculated by compleasm on the cetartiodactyl ODB10 gene set.

  • aIndicates male trio-binned haplotypes including only a Y Chromosome (no X Chromosome), which can result in small genome size, lower N50, reduced gene completeness, etc.

  • bIndicates male F1s that were assembled without parental information, and so X and Y Chromosomes may be split between the dual haplotypes.

This Article

  1. Genome Res. 35: 1041-1052

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