White head in taurine cattle is associated with an SV bubble on Chromosome 6. (A) Purebred white-headed Simmental cow with her daughter showing a large white blaze. The daughter originates from a cross with a Gir sire. The photograph was taken by Hubert Pausch. (B) Mash-based phylogenetic tree of the 24 input taurine assemblies across Chromosome 1. Sample names from breeds with a white/color-headed phenotype are red/black, respectively, whereas each breed cluster on the tree has its own color. (C) Jaccard similarity ratio within 1 kb bins (with respect to the ARS-UCD1.2 reference genome) of the pangenome graph between white-headed and color-headed groups. There were two separate regions of interest, both on Chromosome 6 upstream of KIT (indicated with 1 and 2 in the inset). (D) An ∼150 kb region containing the two regions of interest and the first coding exon of the KIT gene.
