Analysis of alternative C-terminal protein sequences in GENCODE v42. (A) Frequency of alternative C-terminal categories based on splicing or frameshifts being the primary driving factor. (B) Distribution of the frequencies for various splice-driven patterns. (C) Scatterplot of the length of splice-driven C-terminal variation in the reference versus alternative. An example of this category is observed in the TDRD12 gene. TDRD12 undergoes splice-driven alteration causing an alternative terminal exon in TDRD12-202 to harbor the stop codon (D) Scatterplot of the length of frameshift-driven C-terminal variation in the reference versus alternative. Biosurfer plot examples of frameshift-driven category illustrated in GIPC43 and FANCM genes.
