Interactive visualization and interpretation of pangenome graphs by linear reference–based coordinate projection and annotation integration

Table 2.

Performance comparison between VRPG and other pangenome graph visualization tools

Benchmarking task Graph source Graph type Graph builder Graph complexity
(N:node; E:edge)
VRPGa Bandage GfaViz PanGraphViewer
Graph parsing Yeast Full-graph Minigraph N: 37,062
E: 52,756
0.10 sec
64.80 MB
3.50 sec
254.11 MB
247.11 sec
2769.50 Mb
0.22 sec
282.10 MB
Graph parsing Human Full-graph Minigraph N: 424,643
E: 637,628
0.07 sec
54.44 MB
80.35 sec
10,066.50 MB
NA
(memory cap)
7.83 sec
524.38 MB
Minigraph-Cactus N: 80,069,733
E: 110,938,345
0.10 sec
64.73 MB
NA
(memory cap)
NA
(memory cap)
NA
(parsing error)
PGGB N: 110,884,673
E: 154,756,169
0.09 sec
58.26 MB
NA
(memory cap)
NA
(memory cap)
NA
(parsing error)
Graph parsing Human Subgraph > Chr 22 Minigraph N: 9545
E: 14,307
0.01 sec
62.5 MB
1.80 sec
260.15 MB
242.35 sec;
10,083.49 MB
0.19 sec
307.11 MB
Minigraph-Cactus N: 1,279,308
E: 1,780,703
0.01 sec
58.16 MB
84.50 sec
2,120.66 MB
NA
(memory cap)
7.88 sec
815.58 MB
PGGB N: 1,124,300
E: 1,568,024
0.02 sec
56.11 MB
71.05 sec
1890.45 MB
NA
(memory cap)
NA
(parsing error)
Graph rendering Yeast Subgraph > Chr IV:
1–50,000
Minigraph N: 103
E: 142
0.02 sec
82.96 MB
0.76 sec
105.94 MB
0.12 sec
171.48 MB
1.08 sec
323.73 MB
Subgraph > Chr IV: 1–500,000 Minigraph N: 1155
E: 1641
0.02 sec
194.86 MB
1.51 sec
122.36 MB
3.66 sec
324.79 MB
1.68 sec
324.70 MB
Graph rendering Human Subgraph > Chr 22: 20,000,001–20,100,000 Minigraph N: 13
E: 18
0.01 sec
55.24 MB
0.30 sec
103.70 MB
0.16 sec
171.23 MB
0.01 sec
255.26 MB
Minigraph-Cactus N: 2248
E: 3106
0.05 sec
219.78 MB
1.81 sec
129.66 MB
13.25 sec
772.58 MB
1.88 sec
339.91 MB
PGGB N: 2252
E: 3116
0.05 sec
237.48 MB
1.68 sec
129.81 MB
14.15 sec
785.69 MB
NA
(parsing error)
Subgraph > Chr 22: 20,000,001–20,500,000 Minigraph N: 288
E: 435
0.03 sec
82.78 MB
1.33 sec
111.81 MB
0.36 sec
181.08 MB
1.29 sec
321.28 MB
Minigraph-Cactus N: 21,982
E: 30,639
0.18 sec
605.82 MB
19.12 sec
347.27 MB
NA
(memory cap)
7.37 sec
338.50 MB
PGGB N: 66,132
E: 94,595
0.33 sec
1270.61 MB
69.20 sec
766.10 MB
NA
(memory cap)
NA
(parsing error)
  • aThe format conversion (for Minigraph-Cactus and PGGB graphs) step and index building step were performed in advance and were not included in this benchmarking.

This Article

  1. Genome Res. 35: 296-310

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