Haotian Zhang; Yiming Zhang; Teng Gao; Yufeng Wu

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.

Comparison of inference accuracy of ScisTree2 and five other methods: SiFit, SCITE, HUNTRESS, CellPhy, and the original ScisTree on simulated data with 10× coverage. The number of cells was varied in 100, 200, 500, and 1000, the number of variants was set to 5× the number of cells, and methods that did not complete in one day are omitted. The y-axis denotes four performance metrics: genotype accuracy, tree accuracy, AD F-score, and DL F-score.