
An illustration of a pangenome graph encircling individuals from diverse human populations. Pangenome references encompass greater genetic diversity than single-haplotype genome references, promoting equity in genomic research. In this issue, a new method is introduced that genotypes an individual by determining to which haplotypes in the pangenome they are most related. (Cover art illustrated in Adobe Photoshop by Ujjual [www.i-imazine.in]. [For details, see Chandra et al., pp. 2661–2670.])