Cover image

The cover art visually encapsulates the core functionality of the Polyomino algorithm: precisely allocating single cells from transcriptomic data to specific positions in spatial data. The cover depicts a brain in a “building block” style, with regions formed from LEGO-like bricks. Cells descend with parachutes—their colors matching their target brain regions, whether landed or still airborne—symbolizing Polyomino's AI-powered precision in cell navigation, which leverages region-specific insights from spatial data to achieve accurate localization. (Cover art illustrated in Adobe Photoshop by Lihui Lin and Quanyou Cai, based on a concept by Lihui Lin. [For details, see Cai et al., pp. 2513–2526.])