Landscape of APOBEC3A-associated clustered mutation. (A) Observed-to-expected ratios of the intermutational distances between SNVs in each clone. Data are presented as mean ± standard error. (B) Frequencies of clustered mutation events (omikli and kataegis) among A3A-associated base substitutions in clones and cancer genomes. (C) Proportions of classic (in TpCpN context) and nonclassical mutations (in non-TpCpN and NpTpN) in SBS2, SBS13, and kataegis regions in the clones. (D) Comparison of expected and observed number of SNVs in the non-TpCpN context within kataegis regions. (E) Schematic representation of strand-switching kataegis. (F) Strand-switching frequencies of omikli and kataegis across classes of clustered mutation events. (G) A complex strand-switching kataegis involving five switches found in clone A3A_1st_C3_3µg-5. (H) Enrichments of minor strand mutations in the TpCpN context in strand-switching kataegis events.
