Modeling gene interactions in polygenic prediction via geometric deep learning

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Figure 6.
Figure 6.

PRS-Net identifies disease-relevant genes and gene modules for Alzheimer's disease and multiple sclerosis. (A) Top 20 genes ranked by P-values for Alzheimer's disease. P-value by the Mann–Whitney U test. An asterisk preceding the gene name signifies this gene has been reported to be associated with Alzheimer's disease in previous studies. (B) An example of PPIs among PRS-Net-identified genes for Alzheimer's disease. (C) Top 20 genes ranked by P-values for multiple sclerosis. (D) An example of PPIs among PRS-Net-identified genes for multiple sclerosis.

This Article

  1. Published in Advance November 19, 2024, doi: 10.1101/gr.279694.124 Genome Res. 35: 178-187

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