Protein domain embeddings for fast and accurate similarity search

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Figure 3.
Figure 3.

Comparison of the performance of every ESM-2 checkpoint (except t48) by layer on determining if sequence pairs from SCOPe v2.08 are within the same fold or different fold. Checkpoint t30 has the highest performing layers, particularly 15 and 21, which we use as the two layers to generate the DCT fingerprints.

This Article

  1. Published in Advance September 5, 2024, doi: 10.1101/gr.279127.124 Genome Res. 34: 1434-1444

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