CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing

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Figure 3.
Figure 3.

Amplicon reconstruction in cell lines. (A) Fraction of length-weighted copy numbers given by the three heaviest cycles, reported by CoRAL and AA. (B) Number of satisfied subwalk constraints by CoRAL and AA, in cell lines. (C) The cycle with largest length-weighted CN from previously published COLO320-DM. (D) The cycle with largest length-weighted CN from monoclonalized COLO320-DM. In C and D, each blue arc within the cycle indicates a subwalk constraint satisfied by that cycle. (E) The two cycles with largest length-weighted copy numbers by CoRAL. (F) The three cycles with largest length-weighted copy numbers by AA.

This Article

  1. Published in Advance July 9, 2024, doi: 10.1101/gr.279131.124 Genome Res. 34: 1344-1354

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